Dr. Martin’s laboratory has had a long-term interest in investigating the molecular basis of various inherited genetic diarrheal disorders associated with intestinal failure, including Glucose Galactose Malabsorption (SGLT1), enteric anendocrinosis (NEUROG3), and enteric dysendocrinosis (PCSK1). More recently, he has extended his research on intestinal failure to chronic intestinal pseudo-obstruction (CIPO), where he is studying its genetics, and the consequence that such monogenic disorders may have on the intestinal microbiome and metabolome. He has also developed various cell culture models of the human intestinal epithelium and muscularis in order to identify new treatment options for patients with these chronic debilitating disorders